EGFR status and KRAS/BRAF mutations in intestinal-type sinonasal adenocarcinomas
作者： Cristina García-Inclán , Fernando López , Jhudit Pérez-Escuredo , Mari Paz Cuesta-Albalad , Blanca Vivanco
DOI: 10.1007/S13402-012-0103-7
关键词:
摘要: Background Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour that etiologically related to professional exposure wood dust and exhibits poor prognosis. Treatment alternatives surgery radiotherapy are needed may be found in anti-EGFR agents. EGFR gene copy number gains KRAS/BRAF mutations have been reported act as positive negative predictors, respectively, of therapeutic response targeted therapies colorectal adenocarcinoma, type claimed genetically similar ITAC. Therefore, the aim this study was evaluate occurrence consequence alterations KRAS BRAF large series
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