Strong Inference for Systems Biology
作者： Daniel A. Beard , Martin J. Kushmerick
DOI: 10.1371/JOURNAL.PCBI.1000459
关键词:
摘要: Platt's 1964 essay on strong inference [1] illuminates a rational approach to scientific inquiry that integrates seamlessly with current investigations the operation of complex biological systems. Yet in re-examining light trends, it is apparent groundbreaking has failed become universal. Here argued both opportunity and need follow advice are now greater than ever. A revised method for systems biology presented applied analyze longstanding questions cardiac energy metabolism. It shown how this logical framework combined computational-based hypothesis testing unresolved regarding energetic state heart maintained response changes rate ATP hydrolysis.
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