Determinants of Prolonged QT Interval and Their Contribution to Sudden Death Risk in Coronary Artery Disease The Oregon Sudden Unexpected Death Study
作者： Sumeet S. Chugh , Kyndaron Reinier , Tejwant Singh , Audrey Uy-Evanado , Carmen Socoteanu
DOI: 10.1161/CIRCULATIONAHA.108.797035
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摘要: Background— In a recent cohort study, prolongation of the corrected QT interval (QTc) was associated with an independent increased risk sudden cardiac death (SCD). We evaluated determinants prolonged QTc and relationship to SCD among patients coronary artery disease in general population. Methods Results— A case-control design used. Cases were metropolitan area 1 000 residents (2002 2006); controls but no history SCD. All cases required have ECG suitable for analysis before unrelated occurrence total 373 309 met criteria analysis. Mean significantly longer than (450±45 versus 433±37 ms; P<0.0001). multivariate model, gender, diabetes mellitus, QTc-prolonging drugs significant controls. logistic regressio...
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