Alleviation of post-radical prostatectomy cavernosal fibrosis: future directions and potential utility for PDE5 inhibitors.

摘要: Reversion of cavernosal fibrosis remains a controversial issue. The relative smooth muscle cells' loss that happens with nerve damage and their impact on deterioration erectile function were demonstrated in several studies. Furthermore, chronic ischemia occurs aging medical co-morbidities is associated the reduction nitric oxide-cyclic guanosine monophosphate ultimately fibrosis. Despite encouraging recent results role phosphodiesterase type 5 inhibitors prevention post-prostatectomy dysfunction, debate regarding exact mechanism PDE5 prevention, amelioration reversion penile still exists. Recently, reports suggested may improve endothelial decrease arterial stiffness, introducing this class compounds as potential drugs for treatment dysfunction-associated In editorial, we intended to address promising alleviate or reverse ED associated-cavernosal