Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

摘要: Most children with acute lymphoblastic leukemia (ALL) can be cured, but the prognosis is dismal for minority of patients who relapse after treatment. To explore genetic basis relapse, we performed genome-wide DNA copy number analyses on matched diagnosis and samples from 61 pediatric ALL. The typically showed different patterns genomic abnormalities (CNAs), CNAs acquired at preferentially affecting genes implicated in cell cycle regulation B development. lacked some present diagnosis, which suggests that cells responsible are ancestral to primary cells. Backtracking studies revealed corresponding clone were often as minor subpopulations diagnosis. These data suggest contributing ALL selected during treatment, they point new targets therapeutic intervention.