Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4.
作者： Daniella Arêas Mendes-da-Cruz , João Santana Silva , Vinícius Cotta-de-Almeida , Wilson Savino
关键词:
摘要: We previously showed migration disturbances in the thymus during experimental infection with Trypanosoma cruzi, causative agent of Chagas disease. These changes were related to enhanced expression extracellular matrix ligands and receptors, leading escape immature cells periphery. Here, we analyzed role selected chemokines (CXCL12 CCL4) their receptors (CXCR4 CCR5) regulating thymocyte conjunction acute T. cruzi infection. found increased chemokine deposition infected mice when compared controls, accompanied by co-localization fibronectin as well up-regulated surface CXCR4 CCR5 thymocytes. also noticed altered towards analyzed. Such an enhancement was even more prominent added a haptotatic stimulus combination given chemokine. Our findings suggest that results from combined action (ECM), which can be pathological conditions such infection, may at origin T cell repertoire seen this process.
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