Stress response, adrenal steroid receptor levels and corticosteroid-binding globulin levels — a comparison between Sprague-Dawley, Fischer 344 and Lewis rats

摘要: Histocompatible Fischer 344 (F344) and Lewis (LEW) rats provide a comparative model for investigating the interactions between nervous, endocrine immune systems. The outbred Sprague-Dawley (SD) is maternal strain inbred F344 LEW strains. In this study we report large differences in diurnal stress corticosterone (CORT) profiles of these three genetically related strains: (1) had significantly higher CORT levels than SD rats; (2) morning, returned towards basal 1 h after cessation stressor, whereas not to by time; (3) evening, showed expected evening rise levels, failed show rise. light observe absolute Type I (mineralocorticoid) II (glucocorticoid) adrenal steroid receptors neural as well tissue. However, found no significant hippocampus, hypothalamus, pituitary, thymus, spleen peripheral blood mononuclear cells. Similarly, saw most tissues surveyed, with notable exception that binding small, but hippocampus. We also studied corticosteroid-binding globulin (CBG). expressed CBG rats, plasma, thymus. Future studies will investigate whether substantial strains CBG, context few post-adrenalectomy receptor tissue, translate into occupancy/activation under resting conditions, or following stress.