miRNA Multiplayers in glioma. From bench to bedside.

摘要: Glioblastoma multiforme (GBM) is the most common type of malignant gliomas, characterized by genetic instability, intratumoral histopathological variability and unpredictable clinical behavior. Disappointing results in treatment gliomas with surgery, radiation chemotherapy have fuelled a search for new therapeutic targets modalities. A novel small non-coding RNA molecules, microRNAs (miRNAs), appear to represent one attractive target molecules contributing pathogenesis various types tumors. They play crucial roles tumorigenesis, angiogenesis, invasion apoptosis. Some miRNAs are also associated outcome chemo- radiotherapy resistance. Moreover, miRNA potential affect responses molecular-targeted therapies they might be cancer stem cell properties, affecting tumor maintenance progression. The expression profiles useful subclassification GBM, what underscores heterogeneity diseases that all share same WHO grade. Importantly, molecular subtypes GBM correlate phenotypes, characteristic outcomes. then biological markers possible diagnostic prognostic potential. could serve as promising human glioblastoma.