In Silico Investigation of Cancer Using Publicly Available Data

摘要: Cancer is a very complex disease, far more multifaceted than the traditional views rooted in thinking that cancer genomic at least for solid tumors as discussed previous chapters. The disease rapidly evolving biological system drifting away from normal cellular metabolism and homeostasis to adapt also evolving, increasingly challenging unfamiliar microenvironment. It may start some, of itself, seemingly harmless metabolic changes response stressful local condition such persistent hypoxia and/or elevated ROS, which leads gradual continuing microenvironment, hence producing pressure underlying cells evolve. observed cell proliferation represent feasible efficient route affected escape these pressures. similar growth patterns other common characteristics across different types, referred hallmark activities, strongly suggest survival pathway well-coordinated process, possibly guided by signaling instructions manifested hyaluronic acid fragments Chaps. 6 9. continuous coadaptation coevolution between changing microenvironment altered drive utilize whatever capabilities encoded their genomes via relaxed epigenomic regulations or random mutations confer survival.