Development of Dynamic Liquid and Conjugated Electrospun Poly(L-lactide-co-caprolactone)/Collagen Nanoyarns for Regulating Vascular Smooth Muscle Cells Growth.

摘要: Simulating the modeling of smooth muscle layer in vascular structure makes a great difference for tissue regeneration. A functional engineered media shall promote aligned organization and three-dimensional penetration cells (SMCs) into scaffold. To this aim, dynamic liquid conjugated nanoyarns based on poly(L-lactide-co-caprolactone) (P(LLA-CL)) collagen (COL) with weight ratio at 3:1 were fabricated by electrospinning methods, random nanofibers as control groups. The Fourier transform infrared spectroscopy X-ray diffraction analyses confirmed preservation P(LLA-CL)/COL components structure. Scanning electron microscope (SEM) results indicated significant increase yarn diameters 19.27 ± 6.16 μm (dynamic liquid) 10.24 3.09 (conjugated), both had improved mechanical tensile properties than nanofibers. Compared nanofibers, presented higher porosity larger pore diameter, leading to decrease water contact angle promotion SMCs proliferation migration. Better orientation was observed nanoyarns, while superior achieved owing differences yarns microstructure. Herein, study demonstrated that porous beneficial regulating outgrowth, which important implications reconstruction media.