作者: Ovanes Mekenyan , Danail Bonchev
DOI: 10.1016/0223-5234(89)90084-6
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摘要: Abstract The dependence of the biological activity a series congeneric drug compounds on drug's electronic structure is discussed in detail. different types are systematized according to possible mechanisms substrate—receptor interaction. various activity—electronic index correlations thus associated with some specific conjectures about interaction mechanism. increase complexity, due larger number competing side reactions or receptor sites involved, shown probability finding extremum activity.