Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera

摘要: Background Streptococcus pneumoniae (the pneumococcus) is the leading cause of otitis media, community-acquired pneumonia (CAP), sepsis, and meningitis. It now evident that S. forms biofilms during nasopharyngeal colonization; former which facilitates persistence, latter, a prerequisite for subsequent development invasive disease. Proteomic evaluation suggests antigen profile available host-recognition altered as consequence biofilm growth. This has potentially meaningful implications in regards to adaptive immunity protection from disseminated We therefore examined planktonic pneumococcal cell lysates, tested their reactivity with human convalescent sera generated against pneumococci, whether immunization pneumococci protected mice infectious challenge.