Prevention of Der p2-induced allergic airway inflammation by Mycobacterium-bacillus Calmette Guerin.

摘要: Epidemiologic studies suggest an inverse correlation between infection and development of allergy. The purpose this study was to test the hypothesis whether a preexisting T helper 1 (Th1)-type immune response elicited by Mycobacterium bovis-bacillus Calmette-Guerin (BCG) immunization could suppress allergic airway inflammation induced mite allergen Dermatophagoides pteronyssinus group 2 (Der p2) in animal model. C57BL/6 mice were immunized with subcutaneous injection BCG, then intraperitoneal Der p2 emulsified alum. p2-specific immunoglobulin G1 cytokine production from splenocytes measured after sensitization, pulmonary function determined inhalation challenge p2. alum able induce production, which be downregulated pretreatment BCG + inoculation caused produce more interferon-gamma, level higher than that or buffer alone. positive interferon-gamma-staining CD4 cells also increased activation phorbol myristate acetate ionomycin. Lung pathology examination found decreased (associated best least desquamation) inoculated In p2-induced allergy model, can cause Th1-type hinders sensitization inflammation.