In vitro antifungal susceptibility patterns of Trichophyton benhamiae complex isolates from diverse origin.

摘要: Background Species from the Trichophyton benhamiae complex are mostly zoophilic dermatophytes which cause inflammatory dermatophytosis in animals and humans worldwide. Objectives This study was purposed to (a) identify 169 reference clinical dermatophyte strains T species by molecular method adhering newest taxonomy (b) evaluate vitro antifungal susceptibility profile of these against eight common new agents that may be used for treatment dermatophytosis. Methods All isolates, mainly originated Europe but also Iran, Japan USA, were subjected ITS-rDNA sequencing. The profiles drugs isolates determined CLSI M38-A2 protocol according microdilution method. Results Based on sequencing, dominant (n = 102), followed europaeum 29), erinacei 23), japonicum 10), sp 4) eriotrephon 1). MIC ranges across all as follows: luliconazole: 0.0002-0.002 µg/ml, terbinafine: 0.008-0.125 efinaconazole: ciclopirox olamine: 0.03-0.5 itraconazole: 0.06-2 griseofulvin: 0.25-4 amorolfine hydrochloride: 0.125-4 µg/ml tavaborole: 1-16 µg/ml. Conclusion Luliconazole, efinaconazole terbinafine most potent antifungals regardless geographic locations where isolated. These data might help dermatologists develop effective therapies successful infections due species.