Prolonged Second Diagnostic Window for Human Immunodeficiency Virus Type 1 in a Fourth-Generation Immunoassay: Are Alternative Testing Strategies Required?

摘要: Diagnosis of acute HIV is done by patient history and examination testing RNA, proviral DNA, serology using fourth-generation antigen/antibody detection assays. We describe an HIV-1 primary infection with a second diagnostic window 18 to 34 days on immunoassay, which would have been missed some current algorithms. Caution must be exercised when immunoassays are interpreted in isolation, additional should considered depending risk assessment.