Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1

作者: Hiromasa Ooe , Takahiro Taira , Sanae M. M. Iguchi-Ariga , Hiroyoshi Ariga

DOI: 10.1093/TOXSCI/KFI278

关键词:

摘要: DJ-1 was first identified as an activated ras-dependent oncogene. is related to male fertility, and its expression in sperm decreases response exposure a number of reproductive toxicants. has been associated with the onset familial Parkinson's disease (PD) humans, found have activity against oxidative damage by eliminating reactive oxygen species (ROS). In this study, we investigated role stresses administration bisphenol A (BPA), which reported induce stress rodents, mice cultured cells. mice, that BPA significantly increased level brain. Neuro2a GC1 cells, induced ROS production compromised mitochondrial function concomitant elevated oxidization DJ-1. maintain complex I BPA-induced after localization mitochondria. The results showed plays prevention injury-induced cell death.

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