Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis.

摘要: OBJECTIVES To estimate stage-specific transition probabilities in individuals coinfected with HIV and hepatitis C virus (HCV), to examine the effect of covariates on these rates, investigate HCV-related cirrhosis era highly active antiretroviral therapy (HAART). DESIGN Systematic review natural history studies among HCV-infected individuals. METHODS Markov maximum likelihood estimation method was used probabilities. A meta-analysis performed obtain pooled probabilities, a meta-regression impact rates. Risk between monoinfected HCV HIV/HCV were compared by HAART status. RESULTS The estimated mean (95% confidence intervals) annual 3567 (n = 17 studies) as follows: fibrosis stage (F) F0 --> F1 0.122 (0.098-0.153); F2 0.115 (0.095-0.140); F3 0.124 (0.097-0.159); F4 (0.098-0.135) units/year. prevalence after 20 30 years infection 21% (16-28%) 49% (40-59%), respectively. Longer duration significantly associated slower rate progression. overall ratio 27 2.1 (1.5-3.0), 2.5 (1.8-3.4) non-HAART group, 1.7 (1.1-2.8) group. CONCLUSION progression appears constant. Our results confirm that chronic outcomes are worse Over period studied, did not appear fully correct adverse prognosis.