Sensory tractography and robot-quantified proprioception in hemiparetic children with perinatal stroke.

摘要: Perinatal stroke causes most hemiparetic cerebral palsy, resulting in lifelong disability. We have demonstrated the ability of robots to quantify sensory dysfunction children but relationship between such deficits and tract structural connectivity has not been explored. It was aimed characterize dorsal column medial lemniscus (DCML) pathway proprioceptive with perinatal stroke. Twenty-nine participants (6-19 years old) MRI-classified, unilateral ischemic (14 arterial, 15 venous), upper extremity were recruited from a population-based cohort compared 21 healthy controls. Diffusion tensor imaging (DTI) defined DCML tracts five diffusion properties quantified: fractional anisotropy (FA), mean, radial, axial diffusivities (MD, RD, AD), fiber count. A robotic exoskeleton (KINARM) tested limb proprioception an augmented reality environment. Correlations measures parameters evaluated. Lesioned hemisphere lower FA higher MD, AD non-dominant Dominant (contralesional) different Both arterial venous groups impairments that correlated lesioned properties. Sensory is altered correlation suggests clinical relevance possible target for therapeutic intervention. Hum Brain Mapp 38:2424-2440, 2017. © 2017 Wiley Periodicals, Inc.