Mortality Trends in a Population-based Type 1 Diabetes Cohort

摘要: Individuals with type 1 diabetes (T1D) have significantly higher mortality rates than their peers in the general population. Major advances management of T1D occurred during 1980s and 1990s, but recent data on long-term effects overall cause-specific are limited, especially United States. A phenomenon, known as dead-in-bed syndrome, is particular concern it occurs young, healthy individuals who unexpectedly found dead bed. Using follow-up from a large population-based cohort, this dissertation provides contemporary persons long-standing T1D. Cause-specific also explored, focusing how major causes compare to population characterizing deaths that meet criteria for syndrome. Overall, seven times seen diagnosed more recently lower those earlier, even after controlling age. The greatest improvements diabetes-related (diabetic coma, renal disease, cardiovascular or infection), suggesting benefits improved care. In pattern quite contrary what population, females males T1D, causes. While African-Americans much Caucasians racial difference was similar Finally, syndrome appears associated male sex, low BMI, disturbed metabolic control (high HbA1c, high daily insulin dose, history severe hypoglycemia). public health implications considerable, insight into premature permitting development effective targeted preventative strategies. These findings potential change routine care practices address disparities by race sex mortality, resolve life insurance provisions, since antiquated estimates currently used, which do not account treatments.