A Practical Guide to Genome Editing Using Targeted Nuclease Technologies.
作者： Shaina N. Porter , Rachel M. Levine , Shondra M. Pruett‐Miller
DOI: 10.1002/CPHY.C180022
关键词:
摘要: Genome engineering using programmable nucleases is a rapidly evolving technique that enables precise genetic manipulations within complex genomes. Although this technology first surfaced with the creation of meganucleases, zinc finger nucleases, and transcription activator-like effector CRISPR-Cas9 has been most widely adopted platform because its ease use. This comprehensive review presents basic overview genome discusses major technological advances in field. In addition to we discuss CRISPR-derived base editors epigenetic modifiers. We also delve into practical applications these tools, including creating custom-edited cell animal models as well performing screens. Finally, potential for therapeutic ethical considerations related employing humans. © 2019 American Physiological Society. Compr Physiol 9:665-714, 2019.
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