Trans-synaptic regulation of the synthesis of specific neuronal proteins.

摘要: For several decades the main interest in neurobiological research was concentrated on morphological aspects of neuronal systems and electrical manifestations activity. The biochemical studies preferentially concerned static-descriptive approaches particularly those referring to macromolecular constituents neurons. neurons were thought represent relatively stable electronic entities, designed generate, transmit modulate impulses. This attitude interpretation function interneuronal relationship prompted comparison integrated with computers. However, a fundamental difference between computer an system is capability latter adapt changes functional requirements. requirements characterized by term “neuronal plasticity” involves not only composition but even their features. basis for such plastic reactions rapid turnover macromolecules question availability mechanisms which link activity regulation synthesis these macromolecules.