Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase.
作者： William E. Lowry , Jianyun Huang , Ming Lei , David Rawlings , Xin-Yun Huang
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摘要: Abstract Defects in Bruton's tyrosine kinase (Btk) are responsible for X chromosome-linked agammaglobulinemia patients. Mutations each of the structural domains Btk have been detected patients, yet a mechanistic explanation most these mutant phenotypes is lacking. To understand possible role unique pleckstrin homology and Tec (PHTH) module Btk, we compared enzymatic properties full-length lacking PHTH (BtkΔPHTH). Here show that BtkΔPHTH similar basal catalytic activity but very different abilities to recognize protein substrates. Furthermore, domain inactive, contrast prototypical Src retains full ability. These data suggest plays an important substrate recognition, likely interdomain organizations regulations, alterations recognition might play agammaglobulinemia.
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