Antigen Delivery Systems II: Development of Live Recombinant Attenuated Bacterial Antigen and DNA Vaccine Delivery Vector Vaccines

摘要: The development of safe, efficacious recombinant attenuated bacterial antigen delivery systems requires attention to some desired attributes. vaccine design should be focused on—enhancing immunogenicity and the magnitude duration immune response expressed protective antigen, on diminishing potentially competing responses antigens vector. Depending upon disease prevented nature pathogen causing that disease—it may necessary make genetic modifications system, maximize a Th2 important for inducing mucosal systemic antibody or, in other cases, Th1 enhance cellular immunity. It is desirable introduce biological containment features into vaccines prevent their survival persistence environments which they might introduced as consequence immunization. immunity an regard responses, more or less dependent amount delivered immunized host.