作者: M. J. Reed , A. Purohit , L. W. L. Woo , S. P. Newman , B. V. L. Potter
DOI: 10.1210/ER.2004-0003
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摘要: Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates therefore has a pivotal role in regulating formation biologically active steroids. The enzyme widely distributed throughout body, its action implicated physiological processes pathological conditions. crystal structure been resolved, but relatively little known about what regulates expression or activity. Research into control inhibition this stimulated by important supporting growth hormone-dependent tumors breast prostate. STS estrone sulfate dehydroepiandrosterone to dehydroepiandrosterone, respectively, both which can be converted steroids with estrogenic properties (i.e., estradiol androstenediol) that stimulate tumor growth. increased prognostic significance. prompted development potent inhibitors. Several steroidal nonsteroidal inhibitors are now available, irreversible type inhibitor having phenol sulfamate ester as pharmacophore. One such inhibitor, 667 COUMATE, entered phase I trial postmenopausal women cancer. skin also an site activity, deficiency associated X-linked ichthyosis. may involved part immune response some aspects cognitive function. will allow investigation processes.