Steroid sulfatase: molecular biology, regulation, and inhibition.

作者: M. J. Reed , A. Purohit , L. W. L. Woo , S. P. Newman , B. V. L. Potter

DOI: 10.1210/ER.2004-0003

关键词:

摘要: Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates therefore has a pivotal role in regulating formation biologically active steroids. The enzyme widely distributed throughout body, its action implicated physiological processes pathological conditions. crystal structure been resolved, but relatively little known about what regulates expression or activity. Research into control inhibition this stimulated by important supporting growth hormone-dependent tumors breast prostate. STS estrone sulfate dehydroepiandrosterone to dehydroepiandrosterone, respectively, both which can be converted steroids with estrogenic properties (i.e., estradiol androstenediol) that stimulate tumor growth. increased prognostic significance. prompted development potent inhibitors. Several steroidal nonsteroidal inhibitors are now available, irreversible type inhibitor having phenol sulfamate ester as pharmacophore. One such inhibitor, 667 COUMATE, entered phase I trial postmenopausal women cancer. skin also an site activity, deficiency associated X-linked ichthyosis. may involved part immune response some aspects cognitive function. will allow investigation processes.

参考文章(310)
T B Shows, P A Varey, P L Chang, R G Davidson, N E Rosa, O T Mueller, R M Lafrenie, W M Henry, The human arylsulfatase-C isoenzymes: two distinct genes that escape from X inactivation. American Journal of Human Genetics. ,vol. 46, pp. 729- 737 ,(1990)
Ronald Hobkirk, Steroid sulfation Current concepts. Trends in Endocrinology and Metabolism. ,vol. 4, pp. 69- 74 ,(1993) , 10.1016/S1043-2760(05)80018-9
Thomas Golob, Renate Liebl, Erwin von Angerer, Sulfamoyloxy-substituted 2-phenylindoles: antiestrogen-based inhibitors of the steroid sulfatase in human breast cancer cells. Bioorganic & Medicinal Chemistry. ,vol. 10, pp. 3941- 3953 ,(2002) , 10.1016/S0968-0896(02)00306-1
J. M. Esteban, Z. Warsi, M. Haniu, Shiuan Chen, P. Hall, J. E. Shively, Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation. American Journal of Pathology. ,vol. 140, pp. 337- 343 ,(1992)
Shlomo Burstein, Ralph I. Dorfman, Determination of Mammalian Steroid Sulfatase with 7 α-H3-3 β-Hydroxyandrost-5-en-17-one Sulfate Journal of Biological Chemistry. ,vol. 238, pp. 1656- 1660 ,(1963) , 10.1016/S0021-9258(18)81117-6
P L Chang, D G Munroe, Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase. American Journal of Human Genetics. ,vol. 40, pp. 102- 114 ,(1987)
Isabelle Le Roy, Stephane Mortaud, Sylvie Tordjman, Evelyne Donsez-Darcel, Michèle Carlier, Hervé Degrelle, Pierre L. Roubertoux, Genetic correlation between steroid sulfatase concentration and initiation of attack behavior in mice. Behavior Genetics. ,vol. 29, pp. 131- 136 ,(1999) , 10.1023/A:1021664607131
Jadwiga Gniot-Szulżycka, Barbara Januszewska, Purification of steroid sulphohydrolase from human placenta microsomes Acta Biochimica Polonica. ,vol. 33, pp. 203- 215 ,(1986)