Composition and method for the restoration and preservation of transplant organs procured from dcd donors
作者： Mark G. Clemens , Jian X. Zhang , Charles Y. Lee , Shailendra Jain
DOI:
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摘要: The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant and membrane stabilizer agents that can help improve preservation, organ viability, in some cases recover organs would otherwise being unusable for transplantation. In further embodiment, the be used combination with hypothermic machine perfusion. It has been found of prevent or reduce damage to restore organ's anti-oxidant system, stabilize cellular cytoskeleton membranes, inhibit arachidonic acid pathway, provide oncotic support, interstitial edema formation, energy stores within organ. As result, method viability marginal donor organs.
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