Applying DDX3X Biomarker to Discriminate Atypical from Benign Meningiomas in Tissue Microarray.
作者： Wen-Chiuan Tsai , Dueng-Yuan Hueng , Chii-Ruey Lin , Thomas C. K. Yang , Shin Nieh
DOI: 10.1097/PAI.0000000000000422
关键词:
摘要: Patients with atypical meningiomas have a higher recurrence rate and poorer prognosis than patients benign meningeal tumors. However, differentiating from based on fragmented specimens brain tumor biopsy is complicated. We tested the association of DDX3X cytoplasmic expression World Health Organization grading system in various subtypes meningiomas. In our study, was evaluated immunohistochemically 10 non-neoplastic tissues 71 The immunostaining scores were calculated as product intensity percentage positively stained cells. Our results revealed most immunonegative for DDX3X. average score significantly conclusion, immunohistochemistry combined hematoxylin eosin staining may help differentiate
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