Palladium complex-catalyzed intermolecular reductive N-heterocyclization: novel synthesis of quinazoline derivatives from 2-nitrobenzaldehyde or 2-nitrophenyl ketones with formamide
作者： Motohiro Akazome , Jun Yamamoto , Teruyuki Kondo , Yoshihisa Watanabe
DOI: 10.1016/0022-328X(95)05387-5
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摘要: Abstract A combination of the palladium complex PdCl2(PPh3)2 with MoCl5 shows a high catalytic activity for intermolecular reductive N-heterocyclization 2-nitrobenzaldehyde or 2-nitrophenyl ketones formamide to give corresponding quinazoline derivatives in moderate yields. For example, reaction formamide, was obtained 46% yield. We assume that present proceeds via an active nitrene intermediate which would be generated by selective deoxygenation nitro group carbon monoxide.
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