作者: David B. Reitz , Steven M. Massey
DOI: 10.1021/JO00291A058
关键词:
摘要: N-tert-Butyl-N-methyl-2-methoxybenzamide (11) undergoes directed metalation and reaction with methyl iodide to provide N-tert-butyl-N-methyl-2-methoxy-6-methylbenzamide (10) in 98% yield. The potential synthetic usefulness of N-tert-butyl-N-methylbenzamides syntheses was further demonstrated by the synthesis lunularic acid (12) 51% overall yield from 11