Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies

摘要: In the vast majority of cases, clinical solid organ transplantation utilizes organs from brain-dead donors. Brain death imposes hemodynamic, neuroendocrine, and inflammatory stresses upon end organs, which may jeopardize functional structural integrity allografts. Furthermore, these injuries are compounded by cold ischemia associated with preservation. As success relies on optimal condition grafts, beneficial interventions necessary at every stage donation recovery process, starting medical management potential donors, to static storage, “reconditioning” hypothermic machine perfusion. opposed perfusion has many advantages, including reductions in graft primary nonfunction, early allograft dysfunction, postsurgical complications. addition, increased viability marginal might otherwise be deemed unusable some clinicians expand donor pool. Further work dynamic preservation techniques is more efficiently ameliorate brain ischemia.