[Antiganglioside autoantibody profiles in Guillain-Barré syndrome].

摘要: We established anti-ganglioside antibody profiles in GBS and studied the frequency, fine specificity clinical correlate. IgG IgM antibodies to 8 gangliosides were tested by immunodot-blot 249 consecutive patients with Guillain-Barre syndrome large variability expression, referred our laboratory over a 8-year period. anti-GM1 measured Elisa. Thin-layer chromatography overlayed serum was used control positivity. 89/249 (36%) had characteristic profile. Isotypes were, (62%), + (26%) (12%). Antecedent infections found 62% of included more frequently Campylobacter jejuni cytomegalovirus. Various autoantibody described an immunodominant ganglioside. detected 6 ganglioside corresponding immuno-clinical variants GBS: 1) GD1b > acute motor axonal neuropathy after infection 41 GBS; 2) anti-GD1a severe infection; 3) selectively anti-GQ1b 17 typical Miller Fisher areflexia, ataxia ophthalmoplegia; 4) anti- GT1b polysialogangliosides (n = 9) two separate cranial nerve variants, ophthalmoplegic SGB lower depending upon presenting deficit; 5) anti-GD1b 5 pure ataxic sensory (4%); 6) anti-GM2 11 antecedent CMV (8%). 34 (14%) low levels which are not disease specific may simply represent part naturally occurring population or secondary response disease. 126 (50%) no antibodies, predominantly classical form. Associations between isotype, presentation permit definition homogeneous variants. diagnostic prognostic value easy perform immunodot blot peripheral neuropathies.