Chemotherapy in the elderly

摘要: Persons over the age of 65 years are fastest growing segment US population. In next 30 it will comprise 20% More than 50% all cancers occur in this group and therefore, total cancer burden is expected to rise. Data becoming available that better guide use chemotherapy older patient Understanding physiologic functional changes with aging assist developing useful strategies elderly. Pharmacokinetic data on a broad spectrum chemotherapeutic agents be presented. Many these seem have beneficial therapeutic index, particularly patients. There has also been an increasing trend toward oral chemotherapy. Factors must considered choosing include limitations saturability absorption, compliance, pharmacokinetic pharmacodynamic Interpatient variability age-related drug metabolism discussed. Careful attention dose adjustments necessary for end organ dysfunction (renal, hepatic) needed ensure safe administration