Treatment of Advanced Renal-Cell Carcinoma.

Aurelie Guislain, Jules Gadiot, Andrew Kaiser, Ekaterina S. Jordanova, Annegien Broeks, Joyce Sanders, Hester van Boven, Tanja D. de Gruijl, John B. A. G. Haanen, Axel Bex, Christian U. Blank, Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma. Cancer Immunology, Immunotherapy. ,vol. 64, pp. 1241- 1250 ,(2015) , 10.1007/S00262-015-1735-Z

Marie-Therese Haider, Keith D. Hunter, Simon P. Robinson, Timothy J. Graham, Eva Corey, T. Neil Dear, Russell Hughes, Nicola J. Brown, Ingunn Holen, Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo Bone. ,vol. 81, pp. 581- 592 ,(2015) , 10.1016/J.BONE.2015.08.003

Grant D. Stewart, Fiach C. O'Mahony, Alexander Laird, Lel Eory, Alexander L.R. Lubbock, Alan Mackay, Jyoti Nanda, Marie O'Donnell, Peter Mullen, S. Alan McNeill, Antony C.P. Riddick, Daniel Berney, Axel Bex, Michael Aitchison, Ian M. Overton, David J. Harrison, Thomas Powles, Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer Clinical Cancer Research. ,vol. 21, pp. 4212- 4223 ,(2015) , 10.1158/1078-0432.CCR-15-0207

Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596

Matthew R. Smith, Christopher J. Sweeney, Paul G. Corn, Dana E. Rathkopf, David C. Smith, Maha Hussain, Daniel J. George, Celestia S. Higano, Andrea L. Harzstark, A. Oliver Sartor, Nicholas J. Vogelzang, Michael S. Gordon, Johann S. de Bono, Naomi B. Haas, Christopher J. Logothetis, Aymen Elfiky, Christian Scheffold, A. Douglas Laird, Frauke Schimmoller, Ethan M. Basch, Howard I. Scher, Cabozantinib in Chemotherapy-Pretreated Metastatic Castration-Resistant Prostate Cancer: Results of a Phase II Nonrandomized Expansion Study Journal of Clinical Oncology. ,vol. 32, pp. 3391- 3399 ,(2014) , 10.1200/JCO.2013.54.5954

Emma Woodward, Satinder Jagdev, Lucy McParland, Katy Clark, Walter Gregory, Alex Newsham, Suzanne Rogerson, Kate Hayward, Peter Selby, Janet Brown, Skeletal complications and survival in renal cancer patients with bone metastases Bone. ,vol. 48, pp. 160- 166 ,(2011) , 10.1016/J.BONE.2010.09.008

Robert J Motzer, Thomas E Hutson, David Cella, James Reeves, Robert Hawkins, Jun Guo, Paul Nathan, Michael Staehler, Paul de Souza, Jaime R Merchan, Ekaterini Boleti, Kate Fife, Jie Jin, Robert Jones, Hirotsugu Uemura, Ugo De Giorgi, Ulrika Harmenberg, Jinwan Wang, Cora N Sternberg, Keith Deen, Lauren McCann, Michelle D Hackshaw, Rocco Crescenzo, Lini N Pandite, Toni K Choueiri, None, Pazopanib versus Sunitinib in Metastatic Renal-Cell Carcinoma The New England Journal of Medicine. ,vol. 369, pp. 722- 731 ,(2013) , 10.1056/NEJMOA1303989

Jinlu Dai, Honglai Zhang, Andreas Karatsinides, Jill M. Keller, Kenneth M. Kozloff, Dana T. Aftab, Frauke Schimmoller, Evan T. Keller, Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions Clinical Cancer Research. ,vol. 20, pp. 617- 630 ,(2014) , 10.1158/1078-0432.CCR-13-0839

Rana R. McKay, Xun Lin, Julia J. Perkins, Daniel Y.C. Heng, Ronit Simantov, Toni K. Choueiri, Prognostic Significance of Bone Metastases and Bisphosphonate Therapy in Patients with Renal Cell Carcinoma European Urology. ,vol. 66, pp. 502- 509 ,(2014) , 10.1016/J.EURURO.2014.02.040

Robert J Motzer, Bernard Escudier, David F McDermott, Saby George, Hans J Hammers, Sandhya Srinivas, Scott S Tykodi, Jeffrey A Sosman, Giuseppe Procopio, Elizabeth R Plimack, Daniel Castellano, Toni K Choueiri, Howard Gurney, Frede Donskov, Petri Bono, John Wagstaff, Thomas C Gauler, Takeshi Ueda, Yoshihiko Tomita, Fabio A Schutz, Christian Kollmannsberger, James Larkin, Alain Ravaud, Jason S Simon, Li-An Xu, Ian M Waxman, Padmanee Sharma, None, Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma The New England Journal of Medicine. ,vol. 373, pp. 1803- 1813 ,(2015) , 10.1056/NEJMOA1510665