Infantile hemangioma: factors causing recurrence after propranolol treatment
作者： Lei Chang , Dongze Lv , Zhang Yu , Gang Ma , Hanru Ying
DOI: 10.1038/PR.2017.220
关键词:
摘要: BackgroundPropranolol is the first-choice treatment for severe infantile hemangioma (IH). However, 10- 30% of lesions relapse after propranolol treatment. The mechanisms underlying IH recurrence have not been completely elucidated.MethodsThis study combined an examination hemodynamic changes with research regarding stem cells (hscs) differentially expressed microRNAs (miRNAs) to identify factors affecting Hemodynamic were monitored in 21 recurrent cases using high-frequency color Doppler ultrasound, and hscs treated different concentrations propranolol. levels miRNAs activity related pathways then compared between 18 20 non-recurrent cases.ResultsDuring treatment, lesion depth vessel density decreased, resistance index increased. Obvious signals observed cases. Propranolol effectively inhibited proliferation. Twenty-two found group group.ConclusionRecurrence may be attributed a combination events. Serum biomarkers drug treatments must studied further.
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