The Many Faces of Inhibitory Plasticity: Adding Flexibility to Cortical Circuits Throughout Development

摘要: Neocortical circuits are highly interconnected networks of excitatory and inhibitory neurons. During postnatal development the connectivity strength synapses intrinsic properties each neuron type sculpt overall level excitability circuit support network function. Healthy neural characterized by a high sensitivity to changes in environmental stimuli finely tuned dynamic range. A balanced combination inputs endows cortical with ability maintain dynamically stable despite sensory inputs. How this state is achieved during still matter debate. In past few decades, our knowledge neurogenesis, layer differentiation refinement has expanded dramatically. While most research focused on regulation neocortical neurons, it now accepted that contribute substantially achievement maintenance stability Here we will focus recent advancements understanding local their role stability.