Lower Leg Arterial Calcifications Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Hypoparathyroid and Pseudohypoparathyroid Patients.

摘要: Hypoparathyroidism (HypoPT) and pseudohypoparathyroidism (PHP) are diseases with abnormal calcium phosphate homeostasis low high PTH levels, respectively. It has been hypothesized that this could dispose to vascular calcifications thereby perhaps also cardiovascular morbidity. The aim of study was assess lower leg arterial (LLAC) in patients HypoPT or PHP. Using a cross-sectional design, we measured the LLAC using high-resolution peripheral quantitative computed tomography (HR-pQCT) scanner 72 25 PHP compared them findings 61 controls. were found only two (3%) Compared controls, significantly more prevalent (N = 12, [17%], p < 0.01) (N = 4, [16%], p < 0.04). without calcifications, had higher plasma levels eGFR, as well they older often males. Plasma calcium-phosphate product not associated LLAC. In conclusion, an increased prevalence calcifications.