Observation of contrast enhancement in the cochlear fluid space of healthy subjects using a 3D-FLAIR sequence at 3 Tesla

摘要: In animals, the enhancement of perilymph in cochlea has been reported using 1.25 mmol/kg Gd-DTPA, allowing separate visualisation and endolymph for diagnosis Meniere's disease. The purpose this study was three-fold: (1) to determine optimal timing detecting cochlear fluid 3D-FLAIR (fluid-attenuated inversion recovery) after intravenous administration 0.1 Gd-DTPA healthy human subjects; (2) examine reliability multiple (3) investigate whether space can be visually discriminated. two subjects, images were obtained before, immediately 2 h, 4 h 6 injection. Three more subjects scanned before all four ears initial found most intensely enhanced additional three signal had increased from However, visual differentiation could not achieved. Using observed ears, even with a single dose contrast-medium