The infectious and transmissible nature of experimental dental caries. Findings and implications.

摘要: Abstract In both hamsters and Osborne-Mendel rats dental caries appears to be an infectious transmissible disease which involves a penicillin-sensitive flora. The findings reported suggest that if this flora is present or inoculated into young animals, rampant can induced by high-carbohydrate low-fat diet within 35 days. When low negligible has been found in animals similarly fed, the presumably not sufficient quantity pathogenic. Caries activity was markedly reduced after had depressed prior feeding test diet. Hamsters whose depressed, some cases, produced several generations of progeny with activity. Marked differences apparently result from alterations variables acquire, transmit, develop during course experiment. Thus, number interpretations, have made explain observed past studies, must reconsidered terms variations possibly microbic