Insulin is essential for in vitro chondrogenesis of mesenchymal progenitor cells and influences chondrogenesis in a dose-dependent manner
作者： Michael B. Mueller , Torsten Blunk , Bernhard Appel , Angelika Maschke , Achim Goepferich
DOI: 10.1007/S00264-012-1726-Z
关键词:
摘要: Purpose Insulin is a commonly used additive in chondrogenic media for differentiating mesenchymal stem cells (MSCs). The indispensability of other bioactive factors like TGF-β or dexamethasone these medium formulations has been shown, but the role insulin unclear. purpose this study was to investigate whether essential MSC chondrogenesis and if there dose-dependent effect on chondrogenesis.
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