Erlotinib-associated acute pneumonitis: Report of two cases

摘要: Two cases of erlotinib-associated acute pneumonitis are described. The first patient was started on erlotinib treatment for metastatic non-small cell lung cancer. second treated with adenocarcinoma unknown origin. Both patients developed dyspnea and hypoxemia five to six days after initiation treatment. In both cases, computed tomography scan the chest showed extensive bilateral ground-glass infiltrates consistent pneumonitis. patients, resulted in respiratory failure requiring intubation mechanical ventilation. Diffuse alveolar hemorrhage excluded by bronchoscopy cases. Bronchoalveolar lavage cultures were negative. Erlotinib stopped corticosteroids. improved gradually finally discharged a rehabilitation centre, but unfortunately died Klebsiella sepsis. Naranjo causality scale suggested probable association between Literature is sparse. clinical presentation radiographic findings