Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo
作者： Juei-Chuan C. Kang-Sickel , Vandy P. Stober , John E. French , Leena A. Nylander-French
DOI: 10.3109/1354750X.2010.485700
关键词:
摘要: We observed naphthyl-keratin adducts and dose-related metabolic enzyme induction at the mRNA level in reconstructed human epidermis vitro after exposure to naphthalene. Immunofluorescence detection of 2-naphthyl-keratin-1 confirmed metabolism naphthalene adduction keratin. also dermal tape-strip samples collected from naphthalene-exposed workers levels ranging 0.004 6.104 pmol adduct microg(-1) have demonstrated ability skin metabolize form both vivo. The results indicate potential use keratin as biomarkers exposure.
informahealthcare.com参考文章(46)
B. Childs, W. H. Zinkham, A DEFECT OF GLUTATHIONE METABOLISM IN ERYTHROCYTES FROM PATIENTS WITH A NAPHTHALENE-INDUCED HEMOLYTIC ANEMIA Pediatrics. ,vol. 22, pp. 461- 471 ,(1958)
Kathryn Albers, Elaine Fuchs, The Molecular Biology of Intermediate Filament Proteins International Review of Cytology-a Survey of Cell Biology. ,vol. 134, pp. 243- 279 ,(1992) , 10.1016/S0074-7696(08)62030-6
J Schweizer, H Winter, Keratin biosynthesis in normal mouse epithelia and in squamous cell carcinomas. mRNA-dependent alterations of the primary structure of distinct keratin subunits in tumors. Journal of Biological Chemistry. ,vol. 258, pp. 13268- 13272 ,(1983) , 10.1016/S0021-9258(17)44111-1
G Gabbani, S Pavanello, B Nardini, O Tognato, A Bordin, C.Veller Fornasa, G Bezze, E Clonfero, Influence of metabolic genotype GSTM1 on levels of urinary mutagens in patients treated topically with coal tar. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 440, pp. 27- 33 ,(1999) , 10.1016/S1383-5718(99)00013-3
Elaine Fuchs, Howard Green, Changes in keratin gene expression during terminal differentiation of the keratinocyte Cell. ,vol. 19, pp. 1033- 1042 ,(1980) , 10.1016/0092-8674(80)90094-X
Yi-Chun E. Chao, Lawrence L. Kupper, Berrin Serdar, Peter P. Egeghy, Stephen M. Rappaport, Leena A. Nylander-French, Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers Environmental Health Perspectives. ,vol. 114, pp. 182- 185 ,(2006) , 10.1289/EHP.8288
Mayumi Saeki, Yoshiro Saito, Michiyo Nagano, Reiko Teshima, Shogo Ozawa, Jun-ichi Sawada, mRNA Expression of Multiple Cytochrome P450 Isozymes in Four Types of Cultured Skin Cells International Archives of Allergy and Immunology. ,vol. 127, pp. 333- 336 ,(2002) , 10.1159/000057751
Jens M. Baron, Hans F. Merk, Drug metabolism in the skin. Current Opinion in Allergy and Clinical Immunology. ,vol. 1, pp. 287- 291 ,(2001) , 10.1097/01.ALL.0000011028.08297.B3
Petr Pavek, Zdenek Dvorak, Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Current Drug Metabolism. ,vol. 9, pp. 129- 143 ,(2008) , 10.2174/138920008783571774
Suramya Waidyanatha, Melissa A Troester, Andrew B Lindstrom, Stephen M Rappaport, Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats. Chemico-Biological Interactions. ,vol. 141, pp. 189- 210 ,(2002) , 10.1016/S0009-2797(02)00048-0