CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis.
作者： Zhi Zhang , Fanhong Zeng , Huiqing Wen , Bangjian Peng , Jun Weng
关键词:
摘要: Previous literature has indicated that cyclin‐dependent kinase inhibitor 2 A (CDKN2A) is upregulated, while the Protein Inhibitor of Activated STAT1 (PIAS1) is downregulated in the liver tissues of obese mice. The current study aimed to investigate the relationship between CDKN2A and PIAS1 in the lipogenesis of fatty liver disease. In the C57BL/6J db/db mouse model and hepatocyte model of fatty liver, the expression pattern of CDKN2A, PIAS1, Protein arginine methyltransferase 1 (PRMT1) and CASP8 and FADD‐like apoptosis regulator …
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