Aneuploidy and Epithelial Cancers: The Impact of Aneuploidy on the Genesis, Progression and Prognosis of Colorectal and Breast Carcinomas

作者: Jens K. , Gert Auer , Madhvi Upender , Timo Gemoll , Hans-Peter Bruch

DOI: 10.5772/36616

关键词:

摘要: Aneuploidy is a defining feature of epithelial cancers with an impact on the genesis, progression and prognosis these malignancies. Essentially all sporadic, mismatch repair proficient colorectal carcinomas are defined by non-random distribution genomic imbalances. Regarding breast cancer, however, aneuploid near diploid cases show almost similar frequencies. Independent tumor entity, increased levels aneuploidy result in worse clinical outcome. For carcinomas, has been reported as independent prognostic factor comparable to that stage. Unfortunately, translation this knowledge into clinic was slow. Prognostication cancer augmented gene expression profiles poor or good prognosis. Interestingly, there growing evidence signatures simply reflect degree instability. This not surprising since gross nuclear reflected strikingly recurrent entity specific chromosomal Chromosomal imbalances, turn, do significantly modulate resident levels. Furthermore, also affects protein expression. Proteomics therefore become powerful tool unravel potential new targets for diagnostics, prognostication therapeutic stratification. There increasing precedes invasive disease can already be detected premalignant lesions such colon adenomas and/or ulcerative colitis. It reasonable assume plays crucial role during carcinogenesis, interpretation consistent its direct influence triggered considerable efforts elucidate how develops what genetic equilibrium cells at molecular level.

参考文章(92)
Arne Wallgren, Elina Eriksson, Torbjörn Caspersson, Gert Auer, Edward Azavedo, Prognostic Significance of Nuclear DNA Content in Mammary Adenocarcinomas in Humans Cancer Research. ,vol. 44, pp. 394- 396 ,(1984)
Keith R. Loeb, Lawrence A. Loeb, Significance of multiple mutations in cancer. Carcinogenesis. ,vol. 21, pp. 379- 385 ,(2000) , 10.1093/CARCIN/21.3.379
P N Munster, D Marchion, S Thomas, M Egorin, S Minton, G Springett, J-H Lee, G Simon, A Chiappori, D Sullivan, A Daud, Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker. British Journal of Cancer. ,vol. 101, pp. 1044- 1050 ,(2009) , 10.1038/SJ.BJC.6605293
Charles J. Sherr, Mammalian G1 cyclins Cell. ,vol. 73, pp. 1059- 1065 ,(1993) , 10.1016/0092-8674(93)90636-5
JOE HIN TJIO, ALBERT LEVAN, THE CHROMOSOME NUMBER OF MAN Hereditas. ,vol. 42, pp. 1- 6 ,(2010) , 10.1111/J.1601-5223.1956.TB03010.X
RF Willenbucher, SJ Zelman, LD Ferrell, DH Moore, FM Waldman, Chromosomal alterations in ulcerative colitis-related neoplastic progression Gastroenterology. ,vol. 113, pp. 791- 801 ,(1997) , 10.1016/S0016-5085(97)70173-2
Kazuhiro Handa, Mitsunori Yamakawa, Hiroaki Takeda, Seishi Kimura, Tsuneo Takahashi, Expression of cell cycle markers in colorectal carcinoma: Superiority of cyclin A as an indicator of poor prognosis International Journal of Cancer. ,vol. 84, pp. 225- 233 ,(1999) , 10.1002/(SICI)1097-0215(19990621)84:3<225::AID-IJC5>3.0.CO;2-A
E. Schrock, S. du Manoir, T. Veldman, B. Schoell, J. Wienberg, M. A. Ferguson-Smith, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soenksen, Y. Garini, T. Ried, Multicolor Spectral Karyotyping of Human Chromosomes Science. ,vol. 273, pp. 494- 497 ,(1996) , 10.1126/SCIENCE.273.5274.494
S. Yildirim-Assaf, A. Coumbos, W. Hopfenmuller, H.-D. Foss, H. Stein, W. Kuhn, The prognostic significance of determining DNA content in breast cancer by DNA image cytometry: the role of high grade aneuploidy in node negative breast cancer. Journal of Clinical Pathology. ,vol. 60, pp. 649- 655 ,(2007) , 10.1136/JCP.2005.035550
Hassan Ashktorab, Kevin Belgrave, Fatemeh Hosseinkhah, Hassan Brim, Mehdi Nouraie, Mikiko Takkikto, Steve Hewitt, Edward L. Lee, R. H. Dashwood, Duane Smoot, Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Digestive Diseases and Sciences. ,vol. 54, pp. 2109- 2117 ,(2009) , 10.1007/S10620-008-0601-7