作者: Jens K. , Gert Auer , Madhvi Upender , Timo Gemoll , Hans-Peter Bruch
DOI: 10.5772/36616
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摘要: Aneuploidy is a defining feature of epithelial cancers with an impact on the genesis, progression and prognosis these malignancies. Essentially all sporadic, mismatch repair proficient colorectal carcinomas are defined by non-random distribution genomic imbalances. Regarding breast cancer, however, aneuploid near diploid cases show almost similar frequencies. Independent tumor entity, increased levels aneuploidy result in worse clinical outcome. For carcinomas, has been reported as independent prognostic factor comparable to that stage. Unfortunately, translation this knowledge into clinic was slow. Prognostication cancer augmented gene expression profiles poor or good prognosis. Interestingly, there growing evidence signatures simply reflect degree instability. This not surprising since gross nuclear reflected strikingly recurrent entity specific chromosomal Chromosomal imbalances, turn, do significantly modulate resident levels. Furthermore, also affects protein expression. Proteomics therefore become powerful tool unravel potential new targets for diagnostics, prognostication therapeutic stratification. There increasing precedes invasive disease can already be detected premalignant lesions such colon adenomas and/or ulcerative colitis. It reasonable assume plays crucial role during carcinogenesis, interpretation consistent its direct influence triggered considerable efforts elucidate how develops what genetic equilibrium cells at molecular level.