Control of Cerebral Vasospasm by Parenteral Phenoxybenzamine

摘要: Cerebral vasospasm has been studied in the basilar artery of cat. The ability alpha adrenergic blocking agents to prevent and alleviate spasm produced by application blood investigated. Parenteral phenoxybenzamine is effective preventing under these experimental conditions when given doses 12 mg/kg provided at least two hours elapse between administration drug blood. found up 24 after parenteral administration. systemic response blockade effects on different intervals from 1 44 are presented. Although effctive subarachnoid blood, it does not mechanical manipulation vessels. This would indicate that mechanisms other than stimulation itself may be operative i...