Positive and negative affect and risk of coronary heart disease: Whitehall II prospective cohort study

摘要: Objective To examine the associations between positive and negative affect subsequent coronary heart disease events independently of established risk factors. Design Prospective cohort study with follow-up over 12 years. Setting 20 civil service departments originally located in London. Participants 10 308 servants aged 35-55 years at entry into Whitehall II 1985. Main outcome measures Fatal disease, clinically verified incident non-fatal myocardial infarction, definite angina (n=619, mean 12.5 years). Results In Cox regression analysis adjusted for age, sex, ethnicity, socioeconomic position, (hazard ratio=1.01, 95% confidence interval 0.82 to 1.24) balance affect, referred as score ratio=0.89, 0.73 1.09), were not associated disease. Further adjustment behaviour related factors (smoking, alcohol consumption, daily fruit vegetable intake, exercise, body mass index), biological (hypertension, blood cholesterol, diabetes), psychological stress work did change these results. However, participants highest third had an increased incidence ratio=1.32, 1.09 1.60), this association remained unchanged after multiple confounders. Conclusions Positive seem be predictive future men women who free diagnosed recruitment study. A weak was found needs confirmed further studies.