Organ-on-a-chip devices advance to market

作者: Boyang Zhang , Milica Radisic

DOI: 10.1039/C6LC01554A

关键词:

摘要: To curb the high cost of drug development, there is an urgent need to develop more predictive tissue models using human cells determine efficacy and safety in advance clinical testing. Recent insights gained through fundamental biological studies have validated importance dynamic cell environments cellular communication expression fidelity organ function. Building on this knowledge, emerging organ-on-a-chip technology poised fill gaps screening by offering with methods sophisticated assembly. Organ-on-a-chip start-ups begun spawn from academic research commercial space are attracting investment transform discovery industry. This review traces history, examines scientific foundation envisages prospect these renowned technologies. It serves as a guide for new members field navigate existing market space.

参考文章(289)
Michelle Ghert, Nathan Evaniew, Isabella W.Y. Mak, Lost in translation: animal models and clinical trials in cancer treatment. American Journal of Translational Research. ,vol. 6, pp. 114- 118 ,(2014)
Rayat Cs, Joshi K, Datta U, Sakhuja, Glomerular basement membrane thickness in normal adults and its application to the diagnosis of thin basement membrane disease: an Indian study. Indian Journal of Pathology & Microbiology. ,vol. 48, pp. 453- 458 ,(2005)
Jennifer Antonchuk, Formation of Embryoid Bodies from Human Pluripotent Stem Cells Using AggreWell™ Plates Basic Cell Culture Protocols. ,vol. 946, pp. 523- 533 ,(2013) , 10.1007/978-1-62703-128-8_32
Philippe Beauchamp, Wolfgang Moritz, Jens M. Kelm, Nina D. Ullrich, Irina Agarkova, Blake D. Anson, Thomas M. Suter, Christian Zuppinger, Development and characterization of a scaffold-free 3D spheroid model of iPSC-derived human cardiomyocytes Mary Ann Liebert. ,(2015) , 10.1089/TEN.TEC.2014.0376
Maria Stancescu, Peter Molnar, Christopher W. McAleer, William McLamb, Christopher J. Long, Carlota Oleaga, Jean-Matthieu Prot, James J. Hickman, A phenotypic in vitro model for the main determinants of human whole heart function. Biomaterials. ,vol. 60, pp. 20- 30 ,(2015) , 10.1016/J.BIOMATERIALS.2015.04.035
Alexandra Eder, Ingra Vollert, Arne Hansen, Thomas Eschenhagen, Human engineered heart tissue as a model system for drug testing. Advanced Drug Delivery Reviews. ,vol. 96, pp. 214- 224 ,(2016) , 10.1016/J.ADDR.2015.05.010
Shane R Horman, Jeremy To, Anthony P Orth, Nicky Slawny, Meghan J Cuddihy, Diana Caracino, High-content analysis of three-dimensional tumor spheroids: investigating signaling pathways using small hairpin RNA Nature Methods. ,vol. 10, ,(2013) , 10.1038/NMETH.F.370
Christine Fink, Süleman Ergün, Dirk Kralisch, Ute Remmers, Joachim Weil, Thomas Eschenhagen, Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement The FASEB Journal. ,vol. 14, pp. 669- 679 ,(2000) , 10.1096/FASEBJ.14.5.669
Martin N. Nakatsu, Christopher C.W. Hughes, An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods in Enzymology. ,vol. 443, pp. 65- 82 ,(2008) , 10.1016/S0076-6879(08)02004-1
Mi Jang, Pavel Neuzil, Thomas Volk, Andreas Manz, Astrid Kleber, On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics. ,vol. 9, pp. 034113- 034113 ,(2015) , 10.1063/1.4922863