作者: Boyang Zhang , Milica Radisic
DOI: 10.1039/C6LC01554A
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摘要: To curb the high cost of drug development, there is an urgent need to develop more predictive tissue models using human cells determine efficacy and safety in advance clinical testing. Recent insights gained through fundamental biological studies have validated importance dynamic cell environments cellular communication expression fidelity organ function. Building on this knowledge, emerging organ-on-a-chip technology poised fill gaps screening by offering with methods sophisticated assembly. Organ-on-a-chip start-ups begun spawn from academic research commercial space are attracting investment transform discovery industry. This review traces history, examines scientific foundation envisages prospect these renowned technologies. It serves as a guide for new members field navigate existing market space.