Immune Suppressor Mechanisms in HCC

摘要: The liver has been recognized as a tolerogenic organ. This is based on clinical experience in the transplant setting, where immunosuppression dosed relatively low or can even be discontinued selected patients over time. Furthermore, showered with many antigens from gastrointestinal tract delivered through portal vein without causing active immune responses. In contrary, tumor-specific responses against tumors arising have observed. Tumors developed multiple molecular and cellular mechanisms to escape anti-tumor immunity. An increase frequency of myeloid derived suppressor regulatory T cells, two cell types potent function described HCC shown correlate worse outcome. Kupffer cells represent another immunosuppressive different cytokines well surface molecules such PD1/PD-L1 described. A better understanding microenvironment will help understand development growth provide opportunities specifically target mechanism leading enhanced immunity