Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

作者: Giorgia Zadra , Caroline F Ribeiro , Paolo Chetta , Yeung Ho , Stefano Cacciatore

DOI: 10.1073/PNAS.1808834116

关键词:

摘要: … We show that IPI-9119 significantly reduced cell growth and induced cell cycle arrest and apoptosis in PCa … This study sets the stage and provides the rationale for clinical trials to …

参考文章(55)
Giorgia Zadra, Cornelia Photopoulos, Massimo Loda, The fat side of prostate cancer. Biochimica et Biophysica Acta. ,vol. 1831, pp. 1518- 1532 ,(2013) , 10.1016/J.BBALIP.2013.03.010
Scott M. Dehm, Lucy J. Schmidt, Hannelore V. Heemers, Robert L. Vessella, Donald J. Tindall, Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Research. ,vol. 68, pp. 5469- 5477 ,(2008) , 10.1158/0008-5472.CAN-08-0594
Ronald P. Pelley, Kannagi Chinnakannu, Shalini Murthy, Faith M. Strickland, Mani Menon, Q. Ping Dou, Evelyn R. Barrack, G. Prem-Veer Reddy, Calmodulin-Androgen Receptor (AR) Interaction: Calcium-Dependent, Calpain-Mediated Breakdown of AR in LNCaP Prostate Cancer Cells Cancer Research. ,vol. 66, pp. 11754- 11762 ,(2006) , 10.1158/0008-5472.CAN-06-2918
Siu Chiu Chan, Luke A. Selth, Yingming Li, Michael D. Nyquist, Lu Miao, James E. Bradner, Ganesh V. Raj, Wayne D. Tilley, Scott M. Dehm, Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies Nucleic Acids Research. ,vol. 43, pp. 5880- 5897 ,(2015) , 10.1093/NAR/GKV262
Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S. Heuer, Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression EBioMedicine. ,vol. 2, pp. 808- 824 ,(2015) , 10.1016/J.EBIOM.2015.06.020
Martin C. Sadowski, Rebecca H. Pouwer, Jennifer H. Gunter, Amy A. Lubik, Ronald J. Quinn, Colleen C. Nelson, The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget. ,vol. 5, pp. 9362- 9381 ,(2014) , 10.18632/ONCOTARGET.2433
Xiangyan Li, Yi-Ting Chen, Peizhen Hu, Wen-Chin Huang, Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling Molecular Cancer Therapeutics. ,vol. 13, pp. 855- 866 ,(2014) , 10.1158/1535-7163.MCT-13-0797
Johann S. de Bono, Christopher J. Logothetis, Arturo Molina, Karim Fizazi, Scott North, Luis Chu, Kim N. Chi, Robert J. Jones, Oscar B. Goodman, Fred Saad, John N. Staffurth, Paul Mainwaring, Stephen Harland, Thomas W. Flaig, Thomas E. Hutson, Tina Cheng, Helen Patterson, John D. Hainsworth, Charles J. Ryan, Cora N. Sternberg, Susan L. Ellard, Aude Fléchon, Mansoor Saleh, Mark Scholz, Eleni Efstathiou, Andrea Zivi, Diletta Bianchini, Yohann Loriot, Nicole Chieffo, Thian Kheoh, Christopher M. Haqq, Howard I. Scher, Abiraterone and Increased Survival in Metastatic Prostate Cancer The New England Journal of Medicine. ,vol. 364, pp. 1995- 2005 ,(2011) , 10.1056/NEJMOA1014618
Yingming Li, Siu Chiu Chan, Lucas J. Brand, Tae Hyun Hwang, Kevin A.T. Silverstein, Scott M. Dehm, Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines Cancer Research. ,vol. 73, pp. 483- 489 ,(2013) , 10.1158/0008-5472.CAN-12-3630