Emerging and potential therapies for osteoporosis

摘要: Osteoporotic fractures are an important public health problem, contributing substantially to morbidity and mortality in ageing world population consuming considerable resources. Currently available pharmaco-l-ogical therapies for prevention of fragility limited scope, efficacy acceptability patients. Considerable efforts being made develop new, more effective treatments osteoporosis refine/optimise existing therapies. These novel include expanding array drugs that primarily inhibit osteoclastic bone resorption; oestrogenic compounds, bisphosphonates, inhibitors receptor activator nuclear factor-κB ligand signalling, cathepsin K inhibitors, c-src kinase integrin chloride channel inhibitors. The advent intermittent para-thyroid hormone (PTH) therapy has provided proof-of-principle osteo-blast-targeted (anabolic) agents can effectively prevent osteoporotic fractures, is likely be followed ...