Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis
作者： Jose Campos , Federico Román , Marios Georgiou , Concepcion Garcia , Rafael Gómez-Lus
DOI: 10.1093/INFDIS/174.6.1345
关键词:
摘要: Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 microg/mL) high-level ciprofloxacin resistance (MICs, 16-32 are described. The had received several courses ciprofloxacin. These MICs represent decrease susceptibility 200-3200 times. Molecular epidemiologic methods demonstrated that were chronically their own ciprofloxacin-resistant for > or = 15-17 months. showed simultaneous to ampicillin chloramphenicol enzyme inactivation, without beta-lactamase activity. data suggest emergence long-term persistence H. can be consequence antibiotic treatment.
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