Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion.

摘要: This report defines a cell surface receptor (OX40) expressed on effector CD4 T cells, which when engaged in conjunction with danger signal, rescues Ag-stimulated cells from activation-induced death vivo. Specifically, three signals were necessary to promote optimal generation of long-lived memory vivo: Ag, signal (LPS), and OX40 engagement. Mice treated Ag or superantigen (SAg) alone produced very few SAg-specific cells. ligation LPS stimulation, enhanced SAg-driven clonal expansion the survival responding However, SAg was administered at time ligation, synergistic effect observed led 60-fold increase number long-lived, Ag-specific These data lay foundation for provision increased numbers should enhance efficacy vaccine strategies infectious diseases, cancer, while also providing potential target limit auto-Ag-specific autoimmune disease.